Daniel Rosenbaum

Daniel M. Rosenbaum is a professor of biophysics at UT Southwestern Medical Center whose contributions to early atomic-resolution crystal structures of G protein-coupled receptors activated by diffusible ligands helped advance the structural biology of membrane proteins. Rosenbaum earned his undergraduate degree at Princeton University and his doctorate in chemistry at Harvard University, where he worked in David Liu’s lab. During his postdoctoral work in Brian Kobilka’s laboratory at Stanford, he was a lead contributor to the landmark 2007 papers in Science reporting the first high-resolution crystal structure of the human beta-2 adrenergic receptor — the first GPCR for a soluble hormone solved at atomic resolution. Kobilka was awarded the 2012 Nobel Prize in Chemistry for this body of work. Rosenbaum established his own laboratory at UT Southwestern Medical Center in 2010, where he holds a faculty position in the Department of Biophysics and has since solved structures of the orexin, cannabinoid, and dopamine receptors, as well as human sterol transporters relevant to cholesterol regulation. He was promoted to associate professor in 2016 and full professor in 2022.